Crafted with XpresHAn Technology, Restylane Defyne helps smooth out deep laugh lines (nasolabial folds and marionette lines) as well as enhance chin projection. Using innovative cross-linking technology, Restylane Defyne is a hyaluronic acid dermal filler that is able to help restore a more youthful, natural-looking appearance, while helping you maintain your natural expressions and movement.
important safety information
The Restylane family of products are indicated for patients over the age of 21, and includes Restylane, Restylane-L, Restylane Lyft with Lidocaine, Restylane Silk, Restylane Refyne and Restylane Defyne.
Restylane Defyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe deep facial wrinkles and folds, such as nasolabial folds. Restylane Defyne is also indicated for injection into the mid-to-deep dermis (subcutaneous and/or supraperiosteal) for augmentation of the chin region to improve the chin profile in patients with mild to moderate chin retrusion.
Do not use if you have severe allergies with a history of severe reactions (anaphylaxis), are allergic to lidocaine or gram-positive bacterial proteins used to make hyaluronic acid, prone to bleeding, or have a bleeding disorder. The safety of use while pregnant or breastfeeding has not been studied. Tell your doctor if you have a history of scarring or pigmentation disorders as these side effects can occur with hyaluronic acid fillers. Tell your doctor if you are planning other cosmetic treatments (i.e., lasers and chemical peels) as there is a possible risk of inflammation at the injection site.
Tell your doctor if you’re taking medications that lower your body’s immune response or affect bleeding, such as aspirin or warfarin, as these medications may increase the risk of bruising or bleeding at the gel injection site. Using these products on gel injection sites with skin sores, pimples, rashes, hives, cysts, or infections should be postponed until healing is complete.
The most common side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, itching at the injection site, and impaired hand function. Serious but rare side effects include delayed onset infections, recurrence of herpetic eruptions, and superficial necrosis at the injection site. The risk of unintentional injection into a blood vessel is small but can occur and could result in serious complications, which may be permanent including, vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. As with all skin injection procedures, there is a risk of infection.
As we age, our skin loses elasticity. This causes the lines that run along the side of the face and mouth (nasolabial folds and marionette lines) to become more pronounced as well as the chin to recede so far back toward the neck that it creates an imbalance of facial features (chin retrusion). Restylane Defyne is crafted with XpresHAn Technology™ to correct these deepened lines and wrinkles and improve chin projection by correcting mild-to-moderate chin retrusion. The unique cross-linking of the gel in Restylane Defyne is also designed to help support your facial expressions—for natural-looking results that help maintain your natural movement